Sarcomere protein modulation: The new frontier in cardiovascular medicine and beyond

Cristina Morelli,Gessica Ingrasciotta,Daniel Jacoby,Ahmad Masri,Iacopo Olivotto

European Journal of Internal Medicine（2022）

引用 6|浏览4

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摘要

•Allosteric sarcomere protein modulation represents an emerging therapeutic strategy.•Mavacamten and aficamten effectively and safely reduce outflow obstruction in oHCM.•Omecamtiv mecarbil improves systolic function and reduces cardiac events in HFrEF.

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关键词

Sarcomeres,Cardiomyopathies,Heart failure,Neuromuscular diseases, therapeutics

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