Substrate viscosity impairs temozolomide-mediated inhibition of glioblastoma cells' growth

Mateusz Cieśluk,Ewelina Piktel,Urszula Wnorowska,Karol Skłodowski,Jan Kochanowicz,Alina Kułakowska,Robert Bucki,Katarzyna Pogoda

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease（2022）

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摘要

•Hydrogel composition can mimic brain mechanical properties.•Substrate viscosity has significant impact on the apoptosis of treated glioma cells.•Viscosity should be taken into consideration in in vitro drug screening.

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关键词

Rheology,Glioblastoma,Temozolomide,Polyacrylamide hydrogels,Viscoelasticity,Drug effectiveness

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