Foxp2 inhibits Th9 cell differentiation and attenuates allergic airway inflammation in a mouse model of ovalbumin-induced asthma

Xinxing Zhang,Yu Ma,Yanyu He,Wenjing Gu,Yongdong Yan,Wei Ji,Li Huang,Yuqing Wang,Chuangli Hao,Gang Li,Zhengrong Chen

International Immunopharmacology（2022）

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摘要

•Anti IL-9 antibody inhibits abnormal differentiation of Th9 cells in asthmatic mice.•Foxp2 was downregulated in asthmatic mice and Th9 cells.•Overexpression of Foxp2 inhibits Th9 cell differentiation in vitro.•Overexpression of Foxp2 improves airway inflammation in asthmatic mice by inhibiting Th9 cell differentiation.

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关键词

Asthma,Airway inflammation,Th9 cell differentiation,Foxp2

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