Pharmacological Activation of Rev-erb α Attenuates Doxorubicin-Induced Cardiotoxicity by PGC-1 α Signaling Pathway.

Pharmacological activation of Rev-erb by SR9009 could attenuate doxorubicin-induced cardiotoxicity through preservation of mitochondrial function and alleviation of apoptosis and oxidative stress. The mechanism is associated with the activation of PGC-1 signaling pathways, suggesting that PGC-1 signaling is a mechanism for the protective effect of Rev-erb against doxorubicin-induced cardiotoxicity.