Genetic background modulates the sensitivity of Caenorhabditis elegans to the toxic effects of vehicular air pollution.

Vehicular air pollution is an environmental toxicant that can have several health consequences, such as decreased respiratory and cardiovascular function and an increased incidence of age-related dementia and neurodegenerative diseases such as Alzheimer's disease. has been previously shown to be a valuable animal model to study the effects of air pollution due to its tendency to respond to acute exposure to nano-sized particulate matter (nPM) produced by vehicular emissions. Specifically, nPM causes delayed development resulting in smaller animal size and induction of the SKN-1-mediated oxidative stress response. Here we show that various wild isolates demonstrate differential susceptibility to nPM, as measured by body size. Specifically, the Hawaiian isolate, CB4856, displayed the highest sensitivity, equivalent to its sensitivity to the potent oxidant paraquat. The findings described herein suggest that may be a useful genetic tool for identifying nPM-susceptibility loci.