Determination of 5-Formyluracil via Oxime-Based Nucleotide-Metal Coordination

Kaiyuan Zhang,Boshi Fu,Guangrong Zou,Wei Yang,Shen Yan,Tian Tian,Xiang Zhou

CHEMBIOCHEM（2022）

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摘要

2-(Aminooxy)-N-(quinolin-8-yl)acetamide was synthesized, and its ability to regulate activities of DNA polymerase was tested. In addition, we used the isothermal amplification technology to detect the content of 5-formyluracil sites in irradiated genomic DNA, which confirmed its capability for the detection of 5-formyluracil content in general samples. This study presents the first example of the determination of 5fU based on coordination chemistry.

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关键词

DNA-protein interactions, DNA structures, 5-formyluracil, reversible regulation, supramolecular chemistry

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