Risk for bipolar spectrum disorders associated with positive urgency and orbitofrontal cortical grey matter volume

Ann L Carroll,Katherine S F Damme,Lauren B Alloy,Corinne P Bart,Tommy H Ng,Madison K Titone,Jason Chein,Anna C Cichocki,Casey C Armstrong,Robin Nusslock

SSRN Electronic Journal（2022）

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摘要

•Employed a high-risk design to investigate bipolar spectrum disorders (BSD).•Elevated trait positive urgency was found to be a risk factor for developing BSDs.•Relationship between lateral OFC volume and positive urgency differed by BSD risk.•Findings have mechanistic implications for development of impulsivity in BSDs.

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关键词

Bipolar spectrum disorder (BSD),Positive urgency,Grey matter volume,Orbitofrontal cortex (OFC)

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