STEMIN and YAP5SA synthetic modified mRNAs regenerate and repair infarcted mouse hearts.

Siyu Xiao,Rui Liang,Emilio Lucero,Bradley K McConnell,Zhishi Chen,Jiang Chang,Stephen Navran,Robert J Schwartz,Dinakar Iyer

The journal of cardiovascular aging（2022）

引用 3|浏览9

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摘要

STEMIN and YAP5SA mmRNA improved cardiac function and myocardial fibrosis in left ventricles of infarcted adult mice. The combinatorial use of mmRNA encoding STEMIN and YAP5SA has the potential to become a powerful clinical strategy to treat human heart disease.

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关键词

Cardiac regeneration,STEMIN,YAP5SA,heart delivery,hippo pathway,serum response factor,synthetic mRNA

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