Epstein-Barr virus directed screening for nasopharyngeal carcinoma in individuals with positive family history: A systematic review

James C.H. Chow,Anne W.M. Lee,Charlene H.L. Wong,Wai Tong Ng,Zhiwei Liu,Joshua K. Tay,Kwok Seng Loh,Pia Pace-Asciak,Oded Cohen,June Corry,Juan Pablo Rodrigo,Raymond K.Y. Tsang,Fernando Lopez,Nabil F. Saba,Remco de Bree,Alfio Ferlito

Oral Oncology（2022）

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摘要

•The systematic review summarizes the role of EBV-directed familial NPC screening.•Ten cross-sectional studies (n = 7436) and three cohort studies (n = 4306) were included.•EBV positivity rates were high in family members of NPC patients.•Family members of NPC patients who are EBV-positive had high risks of developing NPC.•Familial NPC screening with EBV serology may be warranted in endemic areas.

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关键词

Cancer screening,Epstein-Barr virus,Family,Nasopharyngeal carcinoma,Systematic review

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