Recombinant human chorionic gonadotropin induces signaling pathways towards cancer prevention in the breast of BRCA1/2 mutation carriers.

Yanrong Su,Nhi M Dang,Herman Depypere,Julia Santucci-Pereira,Pedro J Gutiérrez-Díez, Joice Kanefsky,Jaak Ph Janssens,Jose Russo

European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)（2023）

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摘要

Our data suggest that the use of r-hCG at young age may reduce the risk of breast cancer in BRCA1/2 carriers by inhibiting pathways associated with stem/progenitor cell maintenance and neoplastic transformation, whereas activating genes crucial for breast epithelial differentiation and lineage commitment, and DNA repair.

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关键词

breast cancer,cancer prevention,human chorionic gonadotropin,Wnt signaling,MYC,TGFB,BRCA1,TP53

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