Frustrated Lewis pair‐catalyzed hydroboration of nitriles: FLP versus borenium catalysis
Advanced Synthesis & Catalysis(2022)
摘要
A frustrated Lewis pair-catalyzed hydroboration of aromatic and aliphatic nitriles was developed. The catalyst provides the primary amines in high yields of 77-99% with catalyst loading as low as 2 mol%. The reaction displays high functional group tolerance towards esters, amides, nitro groups and aliphatic halides. The addition of the diborylated amines to ethyl 3-phenylpropiolate proceeds with Z-selectivity with d.r. of >99:1 in 77-90% yield over two steps. The reaction mechanism was investigated by control and computational experiments.
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关键词
hydroboration, nitrile, amine, frustrated Lewis pair, density functional theory
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