Novel insights into the relationship between α-1 anti-trypsin with the pathological development of cardio-metabolic disorders

•Inflammatory response and auto-immunity could promote cardio-metabolic disorder diseases.•Anti-inflammatory medicine, such as IL-1 antagonists, manages cardio-metabolic disorder diseases but has side effects.•The α-1 antitrypsin is an endogenous acute phase protein that has multiple immunomodulatory function.•The α-1 antitrypsin could be used as a therapeutic approach for immune related metabolic disease.