Mesenchymal stem cell-derived exosomes altered neuron cholesterol metabolism via Wnt5a-LRP1 axis and alleviated cognitive impairment in a progressive Parkinson’s disease model

Xiaomin Xu,Zongshan Li, Huirong Zuo,Huimin Chen,Yaxing Gui

Neuroscience Letters（2022）

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摘要

•Exosomes isolated during dopaminergic neuron differentiation alleviated cognitive impairment in a progressive Parkinson’s disease model.•Injection of BMSC induced-Exosomes into the striatum altered neuron cholesterol metabolism probably via Wnt5a-LRP1 axis.•Injection of BMSC induced-Exosomes into the striatum altered phospholipid composition in hippocampal neurons in PD mice.

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关键词

Exosomes,Cholesterol,Lipid raft,Parkinson’s disease

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