Population pharmacokinetic/pharmacodynamic modelling of eplontersen, an antisense oligonucleotide in development for transthyretin amyloidosis.

John K Diep,Rosie Z Yu,Nicholas J Viney,Eugene Schneider,Shuling Guo,Scott Henry,Brett Monia,Richard Geary,Yanfeng Wang

British journal of clinical pharmacology（2022）

引用 2|浏览6

暂无评分

摘要

The exposure-response relationship of eplontersen was well characterised by the PKPD model. Weight and injection site were found to affect systemic exposure, but this effect does not seem to result in clinically relevant variation in response.

查看译文

关键词

GalNac3,amyloidosis,antisense oligonucleotide,eplontersen,population pharmacokinetics,transthyretin

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要