Quality of MALDI-TOF mass spectra in routine diagnostics: results from an international external quality assessment including 36 laboratories from 12 countries using 47 challenging bacterial strains.

Aline Cuénod,Martina Aerni, Claudia Bagutti,Banu Bayraktar, Efe Serkan Boz, Cynthia Beisert Carneiro,Carlo Casanova,Alix T Coste,Peter Damborg, Dirk W van Dam,Mehmet Demirci,Pavel Drevinek,Olivier Dubuis,José Fernandez,Gilbert Greub,Jaroslav Hrabak,Gülen Hürkal Yiğitler,Jakub Hurych,Thøger Gorm Jensen, Géraldine Jost,Greetje A Kampinga,Sonja Kittl,Christine Lammens,Claudia Lang,Reto Lienhard, Julie Logan, Carola Maffioli,Ivana Mareković,Matthias Marschal,Jacob Moran-Gilad, Oliver Nolte,Michael Oberle,Michael Pedersen,Valentin Pflüger,Sigrid Pranghofer, Julia Reichl,Rob J Rentenaar,Arnaud Riat,Belén Rodríguez-Sánchez, Camille Schilt,Ann-Kathrin Schlotterbeck,Jacques Schrenzel, Shani Troib, Elise Willems,Mandy Wootton, Dominik Ziegler,Adrian Egli

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases（2023）

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摘要

We have identified simple workflow adaptations, which, to some extent, improve MSQ of poorly performing devices and should be considered by laboratories yielding a low MSQ. Improving MALDI-TOF MSQ in routine diagnostics is essential for increasing the resolution of bacterial identification by MALDI-TOF MS, which is dependent on the reproducible detection of marker masses. The heterogeneity identified in this external quality assessment (EQA) requires further study.

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关键词

Bacterial species identification,Diagnostic performance external quality assessment,MALDI-TOF MS,Quality control,Standardisation

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