A platform trial design for preventive vaccines against Marburg virus and other emerging infectious disease threats.

Ira M Longini,Yang Yang,Thomas R Fleming,César Muñoz-Fontela,Rui Wang,Susan S Ellenberg,George Qian,M Elizabeth Halloran,Martha Nason,Victor De Gruttola,Sabue Mulangu, Yunda Huang,Christl A Donnelly,Ana-Maria Henao Restrepo

Clinical trials (London, England)（2022）

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摘要

This event-driven design takes into the account the potentially sporadic spread of Marburg virus. The proposed trial design may be applicable for other pathogens against which effective vaccines are not yet available.

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关键词

Marburg virus,Randomized placebo-controlled vaccine trial,cluster-randomized vaccine trial,emerging infectious disease threat,vaccine efficacy

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