DDX24 promotes metastasis by regulating RPL5 in non-small cell lung cancer.

Xinyan Hu,Fangfang Li,Yulan Zhou,Hairun Gan,Tiancheng Wang,Luting Li,Haoyu Long,Bing Li,Pengfei Pang

Cancer medicine（2022）

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摘要

DDX24 acted as a pro-tumorigenic factor and promoted metastasis in NSCLC. DDX24 interacted with RPL5 to promote its ubiquitination and degradation. As a result, targeting DDX24/RPL5 axis may provide a novel potential therapeutic strategy for NSCLC.

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关键词

DDX24,RPL5,metastasis,non-small cell lung cancer,ubiquitination

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