Human leukocyte antigen HLA-C, HLA-G, HLA-F, and HLA-E placental profiles are altered in early severe preeclampsia and preterm birth with chorioamnionitis

Caroline E Dunk,Matthew Bucher,Jianhong Zhang,Heyam Hayder,Daniel E Geraghty,Stephen J Lye,Leslie Myatt,Rinat Hackmon

American Journal of Obstetrics and Gynecology（2022）

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摘要

Dysregulation of placental human leukocyte antigen expression at the maternal-fetal interface may contribute to compromised maternal tolerance in preterm birth with chorioamnionitis and excessive maternal systemic inflammation associated with severe early-onset preeclampsia.

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关键词

extravillous trophoblast,human leukocyte antigen,placenta,preeclampsia,preterm birth

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