Antimicrobial effects of inhaled sphingosine against Pseudomonas aeruginosa in isolated ventilated and perfused pig lungs.

Henning Carstens,Katharina Kalka,Rabea Verhaegh,Fabian Schumacher,Matthias Soddemann,Barbara Wilker,Simone Keitsch,Carolin Sehl,Burkhard Kleuser,Michael Hübler,Ursula Rauen,Anne Katrin Becker,Achim Koch,Erich Gulbins,Markus Kamler

PloS one（2022）

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摘要

Inhalation of sphingosine induced a significant decrease of Pseudomonas aeruginosa at the epithelial layer of tracheal and bronchial cells. The inhalation has no local side effects in ex-vivo perfused and ventilated pig lungs.

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