Controlled release of vitamin D 3 using a nanocellulose-based membrane

Epidemiological studies show that a significant fraction of the global population presents low levels of vitamin D 3 . In order to address this problem, one way to administer the vitamin is to incorporate it in novel drug delivery systems, such as transdermal devices. A possible substance for this purpose is cellulose, which has a long history of use in the health area. However, the application of nanostructured cellulose membranes, as local drug delivery systems, remains a challenge. To develop a crystalline nanocellulose membrane as a new tool for the release of vitamin D 3 . A new nanostructured membrane containing nanocellulose extracted from cotton linter and vitamin D 3 was produced using the “casting” technique. The membrane was characterized using high-resolution scanning electron microscopy (FEG-SEM) and Fourier transform infrared spectroscopy (FT-IR). The kinetics of vitamin release was quantified using molecular spectroscopy (UV–Vis). The FT-IR spectra showed the presence of all the active components in the membrane sample, without structural alterations or the formation of new bonds. The FEG-SEM images showed the presence of vitamin crystals on the surface and in the interior of the membrane. The release of vitamin D 3 occurred in a sustained manner, obtaining 3029 IU mL −1 of vitamin D 3 in 60 min. The findings demonstrated that the membrane could be used for the sustained release of vitamin D 3 . This new biomaterial has potential as a new model for vitamin supplementation in individuals with vitamin D 3 deficiency.