What structures did, and did not, reveal about the function of the epithelial Ca2+ channels TRPV5 and TRPV6

Tibor Rohacs,Edwin C Fluck, José J De Jesús-Pérez,Vera Y Moiseenkova-Bell

Cell Calcium（2022）

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摘要

•TRPV5 and TRPV6 are Ca2+ selective epithelial ion channels.•Molecular details of TRPV5 and TRPV6 channels gating.•TRPV5 and TRPV6 structural pharmacology.

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关键词

TRPV5 channel,TRPV6 channel,Cryo electron microscopy,X ray crystallography,Structure-based drug design

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