The conserved Mediator subunit cyclin C (CCNC) is required for brown adipocyte development and lipid accumulation
Molecular Metabolism(2022)
摘要
•CCNC plays different roles at different developmental stages in BAT.•CCNC controls the prenatal BAT development by regulating the proliferation of brown progenitors.•CCNC critically supports lipid accumulation in adult BAT through the C/EBPα/GLUT4/ChREBP axis.
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关键词
CCNC,brown fat,Lipid droplet,Progenitor,Proliferation,Lipogenesis
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