The Sirtuin 1 activator YK 3-237 stimulates capacitation-related events in human spermatozoa

David Martin-Hidalgo,Lauro González-Fernández,M. Julia Bragado,Luis J. Garcia-Marin,Marco G. Alves, Pedro F. Oliveira

Reproductive BioMedicine Online（2022）

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摘要

•SIRT1 is localized in the connecting piece of human spermatozoa.•Lysine acetylation is mainly found along the tail of human spermatozoa.•SIRT1 activation increases tyrosine phosphorylation.•SIRT1 activation improves human sperm responsiveness to Ca2+ ionophore challenge.

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关键词

Acrosome reaction,Capacitation,Human spermatozoa,Protein tyrosine phosphorylation,Sirtuin-1

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