Inefficient Batteries in Heart Failure: Metabolic Bottlenecks Disrupting the Mitochondrial Ecosystem

•Mitochondrial abnormalities have long been described in heart failure.•Reducing mitochondrial function to only a few measures limits our understanding of the entire mitochondrial ecosystem.•Systems biology approaches and comprehensive assessments of the multiple facets of mitochondrial function are needed to advance our understanding of the disturbed mitochondrial ecosystem in heart failure.