Identification of an FXR-modulated liver-intestine hybrid state in iPSC-derived hepatocyte-like cells

Patrick Nell,Kathrin Kattler, David Feuerborn,Birte Hellwig, Adrian Rieck,Abdulrahman Salhab,Konstantin Lepikhov,Gilles Gasparoni, Antonia Thomitzek, Katharina Belgasmi,Nils Blüthgen,Markus Morkel,Barbara Küppers-Munther,Patricio Godoy,David C. Hay,Cristina Cadenas,Rosemarie Marchan,Nachiket Vartak,Karolina Edlund,Jörg Rahnenführer

Journal of Hepatology（2022）

引用 2|浏览24

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摘要

•Human iPSC were differentiated to HLC and characterized by single-cell RNA-seq with complementary epigenetic analyses.•HLC co-expressed liver and intestinal genes in the same individual cells.•Bioinformatics identified low activity of the nuclear factor FXR as one key factor behind mixed cellular identity.•Activation of FXR in HLC induced liver-associated target genes and functions and decreased expression of hybrid state genes.

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关键词

Hepatocyte-like cells,Stem cell,Hybrid,OMICS,Single cell RNA-seq,FXR,Differentiation,Differentiation pattern,Supervised clustering

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