Ethnic differences in ApoC-III concentration and the risk of cardiovascular disease: No evidence for the cardioprotective role of rare/loss of function APOC3 variants in non-Europeans

Madhusmita Rout,Megan Lerner,Piers R Blackett,Marvin D Peyton,Stavros Stavrakis,Evgeny Sidorov,Dharambir K Sanghera

American Heart Journal Plus: Cardiology Research and Practice（2022）

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摘要

These results highlight the challenges of generalizing antisense ApoC-III inhibition for treating atherosclerotic disease in dyslipidemia that may benefit only specific sub-populations. The observed ethnic differences in ApoC-III concentrations and CAD risk factors, emphasize in-depth genetic and metabolomics evaluations on diverse ancestries.

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关键词

Circulating triglycerides,Apolipoprotein C-III concentration,Lipid metabolites,Rare variants,Ethnicity,Cardiovascular disease

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