Randomized controlled trial of pegbovigrastim as an adjunct therapy for naturally occurring severe clinical mastitis cases in dairy cows

Summary: The main objective of this controlled randomized trial was to quantify the impact of pegbovigrastim as an adjunct therapy for severe clinical mastitis cases in dairy cows. A total of 77 cows were enrolled in the study. Cows treated with pegbovigrastim had an improved survival (30 d after treatment) compared with cows that received saline (control), but the treatment had no effect on bacteriological cure at 14 d post-treatment or on daily milk production during the 30-d period following enrollment. These findings improve our understanding of the effect of pegbovigrastim as an adjunct treatment on survival and health in severe mastitis cases in cows.