How to prevent and manage hyperammonemic encephalopathies in valproate therapy

Marleen M M Mitschek,Thomas Vanicek,Jakob Unterholzner,Christoph Kraus,Ana Weidenauer,Angela Naderi-Heiden,Richard Frey,Leo R Silberbauer,Gregor Gryglewski,Konstantinos Papageorgiou,Dietmar Winkler,Markus Dold,Siegfried Kasper,Nicole Praschak-Rieder,Lucie Bartova

Journal of Affective Disorders Reports（2021）

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摘要

•Valproic acid (VPA) can elevate plasma ammonia levels increasing the risk of encephalopathy.•Several other drugs can cause hyperammonemia that might be further triggered by VPA.•Hyperammonemic encephalopathies might require intensive medical care due to mental retardation, lethargy and coma.•Hyperammonemic encephalopathies were associated with urea cycle deficiencies as well as drug interactions.

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