Liquid phase separation techniques for the characterization of monoclonal antibodies and bioconjugates

Journal of Chromatography Open（2022）

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摘要

•Biopharmaceutical products require the characterization of defined critical quality attributes (CQAs).•A wide array of techniques based on orthogonal liquid phase separation principles is available.•Each liquid phase separation technique is suited for the characterization of specific CQAs.•Multidimensional separations allow the simultaneous determination of multiple CQAs.

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关键词

Capillary electrophoresis,Liquid chromatography,Monoclonal antibody,Antibody drug conjugates,Critical quality attributes

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