Effectiveness of BBV152/Covaxin and AZD1222/Covishield vaccines against severe COVID-19 and B.1.617.2/Delta variant in India, 2021: a multi-centric hospital-based case-control study

Tarun Bhatnagar,Sirshendu Chaudhuri,Manickam Ponnaiah,Pragya D Yadav, R Sabarinathan,Rima R Sahay,Faheem Ahmed,S Aswathy,Pankaj Bhardwaj,Anil Bilimale, M Santhosh Kumar, M Logaraj,Uday Narlawar, C Palanivel,Prakash Patel,Sanjay K Rai,Vartika Saxena,Arvind Singh,Jeromie Wv Thangaraj,Ashwini Agarwal,Yasir Alvi, Amoghashree, P Ashok, Dinesh Babu,Yogesh Bahurupi, Sangita Bhalavi,Priyamadhaba Behera, Priyanka Pandit Biswas,Jaykaran Charan,Nishant Kumar Chauhan, K B Chetak,Lalit Dar,Ayan Das, R Deepashree,Minakshi Dhar,Rahul Dhodapkar,T S Dipu,Mridu Dudeja,Manisha Dudhmal,Ravisekhar Gadepalli,Mahendra Kumar Garg, A V Gayathri,Akhil Dhanesh Goel, H Basavana Gowdappa,Randeep Guleria,Manoj Kumar Gupta,Farzana Islam, Mannu Jain,Vineet Jain, M Lanord Stanley Jawahar,Rajendra Joshi,Shashi Kant,Sitanshu Sekhar Kar,Deepjyoti Kalita,Meenakshi Khapre,Satyendra Khichar,Sarika Prabhakar Kombade,Sunil Kohli,Abhinendra Kumar,Anil Kumar,Deepak Kumar,Kiran G Kulirankal, K V Leela,Triparna Majumdar,Baijayantimala Mishra,Puneet Misra,Sanjeev Misra,Prasanta Raghab Mohapatra,M Narayana Murthy,Dimpal A Nyayanit, Manish Patel,Monika Pathania,Savita Patil,Binod Kumar Patro, Ramniwas Jalandra,Pragati Rathod, Naimesh Shah,Anita Shete, Deepak Shukla, M Shwethashree,Smita Sinha, M N Sumana, Ashish Surana,Anjan Trikha,A Tejashree,Mahalingam Venkateshan, G Vijaykrishnan, Sarita Wadhava,Naveet Wig,Nivedita Gupta,Priya Abraham,Manoj V Murhekar

International Journal of Infectious Diseases（2022）

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摘要

•Multi-centric hospital-based study was conducted across 11 cities in India.•Both Covishield and Covaxin confer high protection against severe COVID-19.•Both vaccines provide high protection against severe disease by the Delta strain.•Expansion of the two-dose vaccination coverage is key to reducing hospitalizations.

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关键词

COVID-19 vaccines,BBV152/Covaxin,AZD1222/Covishield,Delta variant,Effectiveness,India

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