Combination of G-CSF and a TLR4 inhibitor reduce inflammation and promote regeneration in a mouse model of ACLF

Cornelius Engelmann,Abeba Habtesion,Mohsin Hassan,Annarein JC. Kerbert,Linda Hammerich,Simone Novelli,Marco Fidaleo, Alexandra Philips,Nathan Davies,Sofia Ferreira-Gonzalez,Stuart J. Forbes,Thomas Berg,Fausto Andreola,Rajiv Jalan

Journal of Hepatology（2022）

引用 19|浏览22

暂无评分

摘要

•We hypothesised that a TLR4 inhibitor, TAK-242, might mitigate the negative effects of G-CSF in ACLF.•G-CSF alone increases mortality and promotes inflammation in rodent models of ACLF.•The combination of TAK-242 and G-CSF inhibits inflammation, promotes hepatic regeneration and prevents mortality in models of ACLF.

查看译文

关键词

liver failure,stem cell therapy,systemic inflammation,regeneration,senescence

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要