Novel insights in antimicrobial and immunomodulatory mechanisms of action of PepBiotics CR-163 and CR-172

Nico van Os,Ali Javed,Femke Broere,Albert van Dijk,Melanie D Balhuizen,Martin van Eijk,Suzan H M Rooijakkers,Bart W Bardoel,Dani A C Heesterbeek,Henk P Haagsman,Edwin Veldhuizen

Journal of Global Antimicrobial Resistance（2022）

引用 2|浏览19

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摘要

•PepBiotics CR-163 and CR-172 are active against ESKAPE pathogens.•Both PepBiotics permeabilize the bacterial outer membrane (OM) and inner membrane (IM).•PepBiotics bind and neutralize Lipopolysaccharide.•PepBiotics kill bacteria in an immunologically silent manner.

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关键词

Antimicrobial peptide,Membrane,Peptide therapeutic,Antimicrobial resistance,Immunomodulation,LPS neutralization

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