Long-term prognostic significance of HER2-low and HER2-zero in node-negative breast cancer

Katrin Almstedt,Anne-Sophie Heimes,Franziska Kappenberg,Marco J. Battista,Hans-Anton Lehr,Slavomir Krajnak,Antje Lebrecht,Mathias Gehrmann,Kathrin Stewen,Walburgis Brenner,Wolfgang Weikel,Jörg Rahnenführer,Jan G. Hengstler,Annette Hasenburg,Marcus Schmidt

European Journal of Cancer（2022）

引用 40|浏览21

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摘要

•Prognosis was assessed in patients with HER2-low and HER2-zero early breast cancer.•Patients with HER2-low breast cancer had a significantly better prognosis.•HER2-low patients had longer disease-free survival and overall survival.•Immunohistochemical HER2 subdivision was confirmed by gene expression analysis.

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关键词

Early breast cancer,HER2-low,HER2-zero,HER2 overexpression,HER2 gene expression,Prognosis

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