Longitudinal Illness- and Medication-Related Brain Volume Changes in Psychosis are Shaped by Connectome Architecture

Distributed grey matter brain regions are connected by a complex structural network of white matter fibres, which are responsible for the propagation of action potentials and the transport of neurochemicals. In neurodegenerative disease, these connections constrain the way in which grey matter volume (GMV) loss progresses. Here, we investigated whether connectome architecture also shapes the spatial patenting of longitudinal GMV changes attributable to illness and/or antipsychotic medication in first-episode psychosis (FEP).