Anti-hyperglycemic potential of alginate oligosaccharide in a high glucose-induced zebrafish model

•AOS exhibits anti-hyperglycemic activity in high-glucose induced hyperglycemic zebrafish.•AOS reduces lactic acid level in hyperglycemic zebrafish.•AOS induces glucose oxidation by enhancing PDHA1 activity via reducing PDK2.•AOS reduces high glucose-induced mortality, oxidative stress and apoptosis.