Protective effects of bitter acids from Humulus lupulus L. against senile osteoporosis via activating Nrf2/HO-1/NQO1 pathway in D-galactose induced aging mice

Shengyan Xu,Tianshuang Xia, Jingwen Zhang,Yiping Jiang,Nani Wang,Hailiang Xin

Journal of Functional Foods（2022）

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摘要

•Bitter acids (BA) from Humulus lupulus L. (hops) are main bitter substances in beer.•BA attenuate senile osteoporosis (SOP) in D-galactose induced aging mice.•BA provided a favorable condition for survival of D-galactose treated osteoblasts.•BA prevent SOP by activating Nrf2/HO-1/NQO1 antioxidant pathway.

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关键词

Bitter acids,Hops,Senescence,Osteoporosis,D-galactose,Nrf2

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