In vitro studies of a series of synthetic compounds for their anti-acetylcholinesterase activities identified arylpyrano[2,3-f]coumarins as hit compounds

Erlon Ferreira Martin,Luiz Antonio Escorteganha Pollo,Layzon Antonio Lemos da Silva,Maique Weber Biavatti,Louis Pergaud Sandjo

Journal of Molecular Structure（2022）

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摘要

•A library of seventy-two synthetic compounds.•Evaluation for their inhibitory effects on acetylcholinesterase.•Pyranocoumarins showed the most potent inhibition.•Molecular docking revealed interesting interactions.

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关键词

Acetylcholinesterase,Pyranocoumarins,Molecular docking,Alzheimer disease

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