Synthesis and cytotoxicity of novel cholesterol–cobalt bis(dicarbollide) conjugates

Anna A. Druzina,Nadezhda Dudarova,Olga B. Zhidkova,Ivan A. Razumov,Olga I. Solovieva,Vladimir V. Kanygin,Vladimir I. Bregadze

Mendeleev Communications（2022）

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摘要

The novel conjugates of cholesterol with cobalt – bis(dicarbollide) were synthesized by the ring-opening reactions of the cyclic oxonium derivatives of [3,3′-Co(C2B9H11)2]– with the OH group of cholesterol 2-hydroxyethyl ether. The compounds obtained were tested for toxicity to glioblastoma U-87 MG cells and human embryo fibroblasts FECH-15 cells

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关键词

boron neutron capture therapy,cancer,boron cage,cobalt bis(dicarbollide),cholesterol,liposomes,lipids,cytotoxicity,human glioblastoma U-87 MG

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