Inflammation and Limb Regeneration: The Role of the Chemokines

Russian Journal of Developmental Biology(2022)

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Abstract
The regeneration of injured tissues is a complex physiological process. The immune system plays an indispensable role in the regeneration process and internal environment stability of damaged tissues. Heavy immune cell infiltration during wound healing stages of regeneration, aggregation of immune cells not only help to remove cell debris, but also secrete chemokines and cell growth factors. Among them, chemo-kines are the key factors in the process of regeneration, including Cys (C), Cys Cys (CC), Cys-x-Cys (CXC) and Cys-x3-Cys (CX3C) subfamilies, which are involved in regulating the migration and activation of immune cells, angiogenesis, functional changes of fibroblasts. This review focuses on the relationship among chemokines and immune cells and regenerative ability during limb regeneration, demonstrates the important contribution of chemokines in limb regeneration of salamander and explores the therapeutic potential of targeting chemokines as a new method to improve tissue regeneration.
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Key words
chemokines,immune cells,regeneration,inflammatory response
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