Solubility and dissolution rate of progesterone cocrystals using 4-fluorobenzoic acid and 2-hydroxy-6-naphthoic acid as coformers

•Improve the solubility and consequently enhance the oral bioavailability of progesterone (P).•Use a suitable co-former to convert the parent compound progesterone into a co-crystal.•Using solution crystallization technology in the stoichiometric ratio of 1: 4 and 1: 2.•The results show that the co-crystal can improve the solubility of progesterone in water.•Pharmaceutical cocrystal can solve the problem of poorly soluble APIs.