Effect of Pu-erh tea on acetaminophen-induced hepatotoxicity assessed by physiological, metabolomic, and transcriptomic analyses

•PTE pretreatment ameliorated oxidative stress, inflammatory response, and apoptosis of mice caused by excess APAP.•PTE pretreatment and APAP overdose altered the metabolic profile and gene expression of liver tissues.•PTE induced tyrosine and caffeine metabolism, and alleviated hepatotoxicity induced by excess APAP.•Six DEMs and 10 DEGs were biomarkers and key genes for liver protection in high dose APAP exposure.