Porous cellulose acetate mixed-matrix membrane adsorbents for efficient clearance of p-cresol and creatinine from synthetic serum

•Porous cellulose acetate (CA) MMMs incorporating various adsorbents (AC, ZO, and GO) were prepared.•The optimal conditions for preparing various MMMs and their surface area/pore properties were determined.•The AC/CA MMM yielded the maximum adsorption of PC (103.0 mg/g) and CRT (137.0 mg/g) at 37 °C.•In closed-loop tests, 82.0% of 50-mg/L PC but 8.0% of 150-mg/L CRT was removed within 4 h using the AC/CA MMM.•The treated media including various MMMs showed excellent biocompatibility, hemocompatibility, and stability.