An isoxazole strategy for the synthesis of 4-oxo-1,4-dihydropyridine-3-carboxylates

Timur O Zanakhov,Ekaterina E Galenko,Mikhail S Novikov,Alexander F Khlebnikov

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY（2022）

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摘要

A method has been developed for the preparation of 2-alkyl-6-aryl-, 2-aryl-6-aryl and 2,6-diaryl-5-arynetaryl-substituted methyl 4-oxo-1,4-dihydropyridine-3-carboxylates by Mo(CO)(6)-mediated ring expansion of methyl 2-(isoxazol-5-yl)-3-oxopropanoates. The high reactivity of 4-oxo-1,4-dihydropyridine-3-carboxylates synthesized provide easy access to 2,4,6-triaryl-substituted and 1,2,5,6-tetrasubstituted nicotinates.

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关键词

isoxazole, methyl nicotinate, molybdenum hexacarbonyl, 4-pyridone, ring expansion

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