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An LNA-amide Modification That Enhances the Cell Uptake and Activity of Phosphorothioate Exon-Skipping Oligonucleotides

Ysobel R. Baker,Cameron Thorpe,Jinfeng Chen, Laura M. Poller, Lina Cox,Pawan Kumar,Wooi F. Lim, Lillian Lie,Graham McClorey,Sven Epple,Daniel Singleton,Michael A. McDonough,Jack S. Hardwick,Kirsten E. Christensen,Matthew J. A. Wood,James P. Hall,Afaf H. El-Sagheer,Tom Brown

Nature Communications（2022）

Cited 22|Views54
Key words
Antisense oligonucleotide therapy,Locked nucleic acid,Structure-based drug design,Science,Humanities and Social Sciences,multidisciplinary
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