Intranasal administration of a live-attenuated recombinant newcastle disease virus expressing the SARS-CoV-2 Spike protein induces high neutralizing antibody levels and protects from experimental challenge infection in hamsters

Rik L. de Swart, Olav S. de Leeuw,Nadia Oreshkova, Nora M. Gerhards,Irina C. Albulescu,Sandra Vreman, José L. Gonzales, Riks Maas,Frank J.M. van Kuppeveld, Peter Soema, Berend-Jan Bosch,Ben P.H. Peeters

Vaccine（2022）

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摘要

•Inoculation of recombinant NDV expressing the SARS-CoV-2 spike protein was immunogenic in hamsters.•Intranasal vaccination provided highest levels of protection against clinical signs, as measured by activity wheel.•NDV constructs encoding the spike of SARS-CoV-2 may be considered as intra-nasal COVID-19 booster vaccines.

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关键词

COVID-19,SARS-CoV-2,Spike protein,NDV,Vaccine

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