Soluble concentrations of the terminal complement complex C5b-9 correlate with end-organ injury in preeclampsia

Catalina M. Valencia,Alyssa R. Hersh,Richard M. Burwick,Jesús A. Velásquez, Jorge Gutiérrez-Marín,Francisco Edna,Jaime L. Silva,Juliana Trujillo-Otálvaro,Johanna Vargas-Rodríguez, Yamile Bernal,Alvaro Quintero,Mónica Rincón,Jorge E. Tolosa

Pregnancy Hypertension（2022）

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摘要

•We evaluated soluble C5b-9 levels in women with hypertensive disorders of pregnancy.•Plasma C5b-9 levels were lowest in patients with hypertension and end-organ injury.•Urine C5b-9 levels were highest in patients with hypertension and end-organ injury.•C5b-9 levels may help identify complement-mediated end-organ injury in preeclampsia.

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关键词

Complement membrane attack complex,Complement system proteins,Hypertension,Preeclampsia,Pregnancy

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