Effects of α5 GABA A receptor modulation on social interaction, memory, and neuroinflammation in a mouse model of Alzheimer's disease.

Jovana Aranđelović,Anja Santrač,Bojan Batinić,Lidija Todorović,Vladimir Stevanović,Veera Venkata Naga Phani Babu Tiruveedhula,Dishary Sharmin,Farjana Rashid,Boban Stanojević,James M Cook,Miroslav M Savić

CNS neuroscience & therapeutics（2022）

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摘要

PAM and NAM failed to exert favorable behavioral effects in transgenic animals. Suppression of neuroinflammation obtained with NAM calls for more studies with GABAergic ligands in amyloid beta- and/or tau-dependent models with prominent neuroinflammation.

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关键词

5xFAD,Alzheimer's disease,cognition,neuroinflammation,α5 GABAA receptor modulation

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