Optimizing treatment selection and sequencing decisions for first-line maintenance therapy of newly diagnosed advanced ovarian cancer – International considerations amongst upper middle- and high-income countries (UMIC and HIC)
Gynecologic Oncology Reports(2022)
摘要
•Early BRCA testing is crucial and enables personalized treatment approach.•BRCA mutation analysis is essential and should be utilized at the time of diagnosis.•Single-agent PARP inhibitors seem most beneficial in BRCA mutations or HRD.•Evidence suggests bevacizumab or niraparib-alone benefits for HRD-negative patients.•HRD-tailored treatment should be explored further.
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关键词
Ovarian cáncer,PARP inhibitors,Genetic testing,BRCA mutations,Olaparib
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