Optimizing treatment selection and sequencing decisions for first-line maintenance therapy of newly diagnosed advanced ovarian cancer – International considerations amongst upper middle- and high-income countries (UMIC and HIC)

Gynecologic Oncology Reports(2022)

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摘要
•Early BRCA testing is crucial and enables personalized treatment approach.•BRCA mutation analysis is essential and should be utilized at the time of diagnosis.•Single-agent PARP inhibitors seem most beneficial in BRCA mutations or HRD.•Evidence suggests bevacizumab or niraparib-alone benefits for HRD-negative patients.•HRD-tailored treatment should be explored further.
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关键词
Ovarian cáncer,PARP inhibitors,Genetic testing,BRCA mutations,Olaparib
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