Assessing fetal human neural stem cells tumorigenicity potential in athymic rats with penetrating traumatic brain injury (pTBI)

MaryLourdes Andreu,Markus Spurlock,Zhen Hu,Angie Sirsy,Liz M Quesada Sanchez,Sakir H Gultekin,Ross Bullock,Shyam Gajavelli

Brain Research（2022）

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摘要

•Transplantation of hNSCs in athymic rats with pTBI is safe.•Ki67 negative engrafted hNSCs did not migrate out of the transplantation site.•Brain lesion volume in athymic rats was not altered by engrafted hNSCs.

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关键词

Athymic rat,Human neural stem cells,Transplantation,Traumatic brain injury,Safety

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