The response of the canine mammary simple carcinoma and carcinosarcoma cells to 5-aminolaevulinic acid-based photodynamic therapy: An in vitro study

Gamze Guney Eskiler,Ozge Turna,Asuman Deveci Ozkan,Aslihan Baykal,Hazal Ozturk Gurgen, Beyzanur Erk,Elif Ilkay Armutak,Hyun Soo Lim

Journal of Photochemistry and Photobiology B: Biology（2022）

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摘要

•5-ALA/PDT significantly reduces the viability of TPC and CS cells.•5-ALA/PDT causes apoptosis in CMGT cells via the activation of pro-apoptotic genes and increased intracellular ROS levels.•PpIX concentration and light fluence affect 5-ALA/PDT response of TPC and CS cells.

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关键词

Canine mammary gland tumor,Photodynamic therapy,5-aminolaevulinic acid,Apoptosis,Carcinoma,Carcinosarcoma

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